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Additional Contact Information: Department of Biomedical Sciences |
EDUCATION/PROFESSIONAL EXPERIENCE:
2025 - Present: Assistant Professor, East Tennessee State University (ETSU)
2019 – 2025: Postdoctoral Fellow, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH)
2014 – 2019: Ph.D. in Pharmaceutical Sciences, University of Maryland School of Pharmacy
2010 – 2014: Bachelors in Science (Biology), University of North Carolina – Chapel Hill
2019 – 2025: Postdoctoral Fellow, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH)
2014 – 2019: Ph.D. in Pharmaceutical Sciences, University of Maryland School of Pharmacy
2010 – 2014: Bachelors in Science (Biology), University of North Carolina – Chapel Hill
RESEARCH INTERESTS:
The main goal of our laboratory is to bridge the gap between preclinical alcohol use
disorder (AUD) and alcohol-associated liver disease (ALD) research. We study mechanisms
that underlie both diseases, contributing to both alcohol consumption and subsequent
organ injury using biochemical, pharmacological, and behavioral models. Ultimately,
we aim to identify novel targetable pathways controlling AUD and ALD initiation and
progression that we can translate to the clinic for AUD and ALD patients.
AWARDS AND FELLOWSHIPS:
2024: NIAAA K99/R00 Pathway to Independence Award
2022, 2024: Fellows Award for Research Excellence, NIH
2017: Transform Tox Testing Challenge Stage 2 Winner (Tox21/EPA/NCATS)
2022, 2024: Fellows Award for Research Excellence, NIH
2017: Transform Tox Testing Challenge Stage 2 Winner (Tox21/EPA/NCATS)
PATENTS:
Inverted Culture Plate System for Cellular Co-Culture
(US Patent # 11,608,483, Issued March 21st, 2023)
Lead Inventor: Bryan Mackowiak / Co-inventors: Hongbing Wang, Linhao Li
(US Patent # 11,608,483, Issued March 21st, 2023)
Lead Inventor: Bryan Mackowiak / Co-inventors: Hongbing Wang, Linhao Li
PUBLICATIONS:
(#indicates corresponding author; * indicates equal contribution)
ORCID ID: 0000-0001-9840-2013
1. Mackowiak B*#, Haggerty D, Lehner T, Lin Y, Fu Y, Lu H, Pawlosky RJ, Ren T, Seo W, Feng D, Zhang L Lovinger D, Gao B#. Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice. Alcohol: Clinical and Experimental Research. 2025. 00, 1-15. PMID: 40114621
2. Fu Y*, Mackowiak B*, Lin Y, Lehner T, Pan H, Guan Y, Godlewski G, Lu H, Cheng C, Maccioni L, Feng D, Paloczi J, Pacher P, Zhang L, Kunos G, Gao B. Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption. Nature Metabolism. 2024. 6, 1380–1396. PMID: 38902331
3. Mackowiak B*, Fu Y*, Macconi L, Gao B. Alcohol-associated Liver Disease. The Journal of Clinical Investigation. 2024. 134(3):e176345. PMID: 38299591
4. Lehner T, Gao B#, Mackowiak B#. Alcohol metabolism in alcohol use disorder: a potential therapeutic target. Alcohol and Alcoholism. 2023. 59: 1. PMID: 37950904
5. Mackowiak B*, Xu M*, Lin Y, Guan Y, Seo W, Ren R, Feng D, Jones JW, Wang H, Gao B. Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute-on-chronic alcohol-induced liver injury. Alc Clin Exp Res. 2022. 46(12):2163-2176. PMID: 36224745
6. Mackowiak, B.; Li, L.; Lynch, C.; Ziman, A.; Heyward, S.; Xia, M.; Wang, H. High-content analysis of constitutive androstane receptor (CAR) translocation identifies mosapride citrate as a CAR agonist that represses gluconeogenesis. Biochemical Pharmacology. 2019. 168: 224-236. PMID: 31306645
7. Mackowiak, B.; Hodge, J; Stern, S; Wang, H. The Roles of Xenobiotic Receptors: Beyond Chemical Disposition. Drug Metab Dispos. 2018. 46 (9): 1361-1371. PMID: 29759961
8. Mackowiak, B.; Li, L.; Welch, M.A.: Li, D.; Jones, J.; Heyward, S.; Kane, M.; Swaan, P.; Wang, H. Molecular basis of metabolism-mediated conversion of PK11195 from an antagonist to an agonist of the constitutive androstane receptor. Mol Pharm. 2017. 92 (1): 75-87. PMID: 28442602
9. Mackowiak, B. & Wang, H. Mechanisms of Xenobiotic Receptor Activation: Direct vs. Indirect. BBA Gene Regulatory Mechanisms. 2016. 1859 (9): 1130-1140. PMID: 26877237